GLP-1 is a type of glucagon that is secreted from the intestines during eating and suppresses appetite, leading to clinically beneficial weight loss, as well as reduced blood pressure and cholesterol levels. It also reduces gastric emptying and gut motility, which allows you to feel fuller, and for longer. Lastly, GLP-1 increases the release of insulin – which allows the cells in the muscles, fat and liver to absorb glucose (sugar) in the blood. The weight loss observed in patients using GLP-1 can be seen in the reduction of total body fat, but may particularly target visceral (abdominal/belly) fat, which is the kind of fat most detrimental to overall health.
The greatest weight loss was seen when patients stuck to a low-carbohydrate lifestyle, greatly reduced alcohol & fat intake, and maintained a regular exercise routine. Results are seen fairly quickly, usually within a couple of weeks. Unlike strict dietary changes alone which can produce short-term results but can be difficult to maintain, weight loss with GLP-1 is sustained for an average of at least 3 years making it more beneficial for long term health and maintenance.